John G McHutchison Selected Research

CPG 10101

11/2007

Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus.

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John G McHutchison Research Topics

Disease

115	Infections 01/2021 - 03/2002
83	Chronic Hepatitis C 07/2018 - 03/2002
63	Fibrosis (Cirrhosis) 12/2019 - 03/2002
37	Hepatitis C 01/2019 - 04/2002
15	Anemia 01/2017 - 04/2002
14	Chronic Hepatitis B 07/2017 - 04/2008
13	Liver Diseases (Liver Disease) 01/2019 - 10/2005
11	Headache (Headaches) 01/2019 - 08/2007
10	Virus Diseases (Viral Diseases) 04/2015 - 06/2003
9	Liver Cirrhosis (Hepatic Cirrhosis) 12/2019 - 03/2003
7	Fatigue 01/2019 - 04/2013
7	Hemolytic Anemia 09/2017 - 05/2006
6	Inflammation (Inflammations) 01/2018 - 03/2002
6	Nausea 01/2017 - 04/2013
6	Persistent Infection 01/2017 - 10/2005
6	Hepatitis 06/2016 - 03/2002
5	Non-alcoholic Fatty Liver Disease 12/2019 - 08/2007
5	Disease Progression 12/2019 - 11/2002
5	Body Weight (Weight, Body) 08/2011 - 03/2002
4	Hepatitis B 01/2018 - 08/2007
4	Nasopharyngitis 01/2018 - 06/2015
4	Cytopenia 09/2017 - 10/2005
4	Exanthema (Rash) 11/2011 - 08/2008
4	Hemolysis 04/2011 - 11/2002
3	HIV Infections (HIV Infection) 01/2019 - 07/2014
3	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 05/2006
3	Coinfection 07/2017 - 03/2015
3	Neutropenia 05/2013 - 12/2007
3	Insulin Resistance 09/2012 - 07/2011
2	Reinfection 01/2021 - 01/2015
2	Sclerosing Cholangitis 01/2019 - 08/2007
2	Diarrhea 01/2017 - 01/2017
2	Respiratory Tract Infections (Respiratory Tract Infection) 11/2016 - 11/2016
2	Renal Insufficiency (Renal Failure) 11/2014 - 07/2005
2	Lymphopenia (Lymphocytopenia) 04/2014 - 08/2007

Drug/Important Bio-Agent (IBA)

93	Ribavirin (Virazole)FDA LinkGeneric 01/2019 - 03/2002
56	SofosbuvirIBA 01/2021 - 04/2013
53	InterferonsIBA 01/2019 - 03/2002
47	Antiviral Agents (Antivirals)IBA 01/2021 - 03/2002
23	ledipasvirIBA 01/2019 - 07/2012
22	sofosbuvir drug combination ledipasvirIBA 01/2019 - 02/2014
19	RNA (Ribonucleic Acid)IBA 01/2021 - 03/2002
17	NucleotidesIBA 01/2018 - 05/2013
14	velpatasvirIBA 01/2021 - 12/2015
13	Interferon-alpha (Interferon Alfa)IBA 01/2015 - 05/2004
11	Protease Inhibitors (Protease Inhibitor)IBA 01/2017 - 04/2009
9	Biomarkers (Surrogate Marker)IBA 12/2019 - 12/2004
9	Proteins (Proteins, Gene)FDA Link 01/2017 - 12/2004
8	Alanine Transaminase (SGPT)IBA 07/2017 - 03/2002
8	Tenofovir (Viread)FDA Link 01/2017 - 02/2013
8	peginterferon alfa-2a (Pegasys)FDA Link 04/2014 - 08/2008
7	Pharmaceutical PreparationsIBA 01/2021 - 02/2006
6	albinterferon alfa-2bIBA 10/2010 - 06/2008
5	simtuzumabIBA 12/2019 - 01/2018
5	CreatinineIBA 01/2017 - 07/2011
5	voxilaprevirIBA 01/2017 - 01/2016
5	telaprevirIBA 11/2011 - 08/2008
5	Interferon alpha-2 (Roferon-A)FDA Link 10/2010 - 03/2002
4	Interferon LambdaIBA 01/2019 - 06/2010
4	sofosbuvir velpatasvir voxilaprevir drug combinationIBA 01/2018 - 01/2017
4	TabletsIBA 01/2018 - 04/2014
4	Emtricitabine (Emtriva)FDA Link 01/2017 - 04/2014
4	Hepatitis B e AntigensIBA 11/2016 - 05/2014
4	GS-9451IBA 02/2016 - 01/2013
4	CytokinesIBA 12/2014 - 06/2006
4	NucleosidesIBA 07/2014 - 11/2002
4	Inosine TriphosphataseIBA 02/2012 - 10/2010
4	peginterferon alfa-2b (Pegintron)FDA Link 02/2011 - 09/2003
4	Human Serum Albumin FDA LinkGeneric 10/2010 - 04/2006
3	CollagenIBA 12/2019 - 01/2018
3	InterleukinsIBA 01/2019 - 07/2010
3	Lamivudine (Epivir)FDA Link 01/2017 - 04/2008
3	tenofovir alafenamideIBA 11/2016 - 03/2015
3	GS-9669IBA 02/2016 - 03/2014
3	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2016 - 05/2014
3	VaccinesIBA 01/2016 - 11/2002
3	Drug CombinationsIBA 01/2016 - 10/2005
3	vesatolimodIBA 08/2015 - 01/2013
3	Toll-Like Receptor 7IBA 01/2015 - 08/2007
3	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 12/2014 - 12/2004
3	Hyaluronic Acid (Hyaluronan)IBA 12/2014 - 03/2003
3	CholesterolIBA 07/2012 - 06/2010
3	Erythropoietin FDA Link 04/2007 - 11/2003
2	Alkaline PhosphataseIBA 01/2019 - 05/2010
2	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2019 - 10/2018
2	selonsertibIBA 10/2018 - 01/2018
2	Monoclonal AntibodiesIBA 10/2018 - 02/2009
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 11/2016
2	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 12/2014 - 07/2007
2	Interleukin-12 (IL 12)IBA 12/2014 - 06/2003
2	tegobuvirIBA 07/2014 - 03/2012

Therapy/Procedure

70	Therapeutics 01/2019 - 03/2002
14	Liver Transplantation 01/2018 - 03/2002
8	Drug Tapering 04/2014 - 10/2005
5	Transplantation 05/2017 - 12/2013
5	Duration of Therapy 11/2016 - 01/2009
3	Aftercare (After-Treatment) 10/2018 - 03/2003
3	Retreatment 10/2017 - 11/2011
3	Contraindications 11/2015 - 12/2007
2	Subcutaneous Injections 01/2019 - 10/2018